A. Replacement therapy in:

• Primary immunodeficiency syndromes (PID) such as:
– congenital agammaglobulinaemia and hypogammaglobulinaemia
– common variable immunodeficiency
– severe combined immunodeficiency
– Wiskott-Aldrich syndrome

• Myeloma or chronic lymphocytic leukaemia with severe secondary hypogammaglobulinaemia and recurrent infections
• Children with congenital AIDS and recurrent infections

B. Immunomodulation:

• Immune thrombocytopenic purpura (ITP) in children or adults at high risk of bleeding or prior to surgical interventions to correct the platelet count
• Guillain-Barré syndrome
• Kawasaki disease
• Chronic inflammatory demyelinating polyneuropathy (CIDP)

C. Allogeneic bone marrow transplantation